When Dr. Jonathan Ohnn first announced himself as The Spot, Spider-Man collapsed on the rooftop, laughing at the name. The Spot ended up winning that first confrontation but lost a second battle because he was tricked into throwing too many of his spots as weapons and not keeping enough to defend himself with.
The original Hobgoblin (Amazing Spider-Man #238) was amoral billionaire fashion designer Roderick Kingsley who had become obsessed with Norman Osborn, the original Green Goblin, after discovering the locations of his various hideouts. When Kingsley's villainous identity was finally exposed, he fled to the Caribbean to escape prosecution.
When Miguel O'Hara, a brilliant geneticist living in New York in the year 2099 A.D., attempted to recreate the abilities of the original Spider-Man in other people, he suffered an accident that caused half his DNA to be re-written with a spider's genetic code.