The Diamondbacks' first major league game was played against the Colorado Rockies on March 31, 1998, at Bank One Ballpark.

The Diamondbacks defeated the New York Yankees in the 2001 World Series, becoming the fastest expansion team in Major League history to win a championship, which it did in just its fourth season.

Randy Johnson won a total of five Cy Young Awards during his career, four of them consecutively with the Diamondbacks (1999-2002).

On March 24, 2001, Diamondbacks all-star Randy Johnson's fastball famously exploded a dove mid-flight. After the pitch hit the bird, the ball was ruled dead. The bird was also ruled dead.

Arizona's pitching held powerhouse New York to a .183 batting average, the lowest ever in a seven-game World Series.

In 1999, Womack led the major leagues with 72 stolen bases.

On September 24, 2019, one day after being eliminated from postseason contention, the team made history with a 3-2 win over the St. Louis Cardinals that lasted 19 innings (5 hours and 46 minutes) and featured an appearance by a franchise-record 30 Diamondbacks players.

On May 18, 2004, Randy Johnson pitched a perfect game against the Atlanta Braves. Johnson, who was 40 at the time, was the oldest pitcher in MLB history to throw a perfect game, surpassing Cy Young who was 37 when he threw his perfect game in 1904.

The D-backs were hoping that Schilling would help them repeat as NL West champs, but the team struggled down the stretch and missed the postseason. The trade paid big dividends the next year though as Schilling won 22 games and shared 2001 World Series MVP honors with Randy Johnson.

The Diamondbacks starting lineup for the World Series did not include a player under the age of thirty-one, making them the oldest team by player age in World Series history. With several players nearing the age of retirement, Luis Gonzalez noted that the overall team mentality was "there's too many good guys in here to let this opportunity slip away."