The Bills began play as an original franchise of the American Football League (AFL) in 1960.

Although he was fired by Bills owner Ralph C. Wilson Jr. after only two seasons, Ramsey is credited for laying the foundation of one of the best defensive teams in the history of the AFL.

Employing the "K-Gun" offense, known for its no-huddle shotgun formations, QB Jim Kelly led the Bills to a record four consecutive Super Bowls.

In his 19 NFL seasons, Smith played in 279 games, amassing 200 sacks. As he spent most of his career in a 3-4 defensive scheme that wasn't geared toward creating sack opportunities for defensive ends, many consider the record particularly impressive.

Thomas missed the first two plays of Buffalo's first drive because he misplaced his helmet.

The Bills won two consecutive American Football League titles in 1964 and 1965 with quarterback Jack Kemp and coach Lou Saban.

O.J. Simpson was the only player to ever rush for over 2,000 yards in the 14-game regular season NFL format.

Scott Norwood is best known for missing a game-winning field goal attempt at the end of Super Bowl XXV.

While with the Bills, Talley had multiple nicknames, including "The Duke of Awesome", "Spider-Man", and "The Hammer". His cheering section at Rich Stadium was known as the "Talley-Whackers".

After Buffalo QB Frank Reich lost a fumble, Dallas tackle Leon Lett picked up the ball with no one in front of him and appeared ready to score on a 64-yard touchdown return. As Lett started to showboat just before crossing the goal line, hustling Buffalo wide receiver Don Beebe ran Lett down from behind and stripped the ball.