A 4-year-old Alicia Keys made her acting debut in the episode where Rudy had a birthday party. She sat on Cliff's lap when he played a riding horse.

DiCaprio only appeared in one episode of Santa Barbara, but it earned him a nomination for Best Young Actor in a Daytime Series.

In 2003, a masked serial killer murdered a huge chunk of the show's most beloved characters. Who would do such a thing? Turned out it was a brainwashed Marlena Evans killing off her friends and neighbors!

In "Homer's Odyssey", Waylon Smithers was accidentally made African American by the color stylist. Smithers' skin tone in this episode was later explained as an "extreme tan".

Other children and classmates are alienated by Cartman's insensitive, racist, xenophobic, anti-semitic, lazy, self-righteous behavior, but still find themselves influenced occasionally by his manipulative, and propagandist schemes.

In the episode "The Strong Box", Kramer says one of the things in his strongbox is his military discharge. Upon being asked, "You were in the Army?", Kramer replies, "Briefly," and claims the reason for his discharge is classified.

Archie longs for better times when people sharing his viewpoint were in charge, as evidenced by the nostalgic theme song "Those Were the Days" (also the show's original title).

In "The Seminar", Lou takes Mary with him to a broadcast seminar in Washington, D.C., promising to introduce her to all the political movers and shakers. The promised gathering doesn't seem to materialize, and Mary ends up going to a party with several minor government officials. When she returns to Lou's room, he tells her she's just missed astronaut John Glenn, journalist Eric Sevarid, Ethel Kennedy, former Vice President Hubert Humphrey, and the President and Mrs. Ford, but she doesn't believe him -- even after he gets a phone call from First Lady Betty Ford asking if the President has left his pipe in the hotel room.