The Darkness, also known as Amara, is a supremely powerful primordial entity who has existed since before the beginning of time. Due to her penchant for destruction, she was sealed away by her brother, God.

Seen entirely in and around the Impala, "Baby" (Season 11, episode 4) features Sam and Dean taking down an army of ghoul and vampire-like creatures called Nachzehrers.

In "The Chitters", Sam and Dean team up with Cesar and Jessy, who happen to be a gay couple.

When Amara's fog wipes out a whole town, it results in an atheist named Donatello being called as a Prophet. In the following episode ("We Happy Few"), Amara eats Donatello's soul.

Dagon is a Prince of Hell, the first generation of demons after Lilith, created by Lucifer himself. Despite being the rightful heirs to Lucifer's throne, Dagon and her brothers Ramiel and Asmodeus opt to retire on earth, with only Azazel assuming rule over Hell to continue their father's work.

When Lucifer possesses the body of President Jefferson Rooney, he conceives a Nephilim with Kelly Kline, a member of Rooney's staff.

With the help of Billie the Reaper, Sam and Dean are able to get the souls they need to destroy The Darkness. "Dead folks," Billie says, "kind of my thing."

In Season 11, God writes an autobiography, entitled God: An Autobiography, which Metatron later characterizes as more of a suicide note.

Gunner Lawless, one of Dean's childhood heroes, has sold his soul to a crossroads demon named Duke, but later redeems himself by killing Duke to save Dean.

God sealed his sister Amara away using the Mark of Cain as both a lock and key.